Discover Your Perfect Lake Nona Medical City Vacation Homes

Lake Nona Medical City Luxury Rentals

9.4 (6 Reviews)
House
Nona Retreat
  • Air Conditioner
  • Pet Friendly
  • Pool
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Why Choose Rent By Owner for your Lake Nona Medical City Vacation Rental Homes?

What makes our Vacation Rentals special?

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Verified Listings
Book with confidence knowing every property meets our quality and safety standards.
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Unbeatable Value
Enjoy competitive pricing with no hidden fees, providing exceptional value for every stay.
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Diverse Options
From cozy cabins to luxurious villas, find a rental that suits your style and needs.

Popular Areas for Lake Nona Medical City Vacation Rentals

Where are the best neighborhoods to stay in Lake Nona Medical City?

Exploring the neighborhoods around Lake Nona Medical City offers a unique opportunity to experience a vibrant and growing community in Orlando, Florida. Whether you’re seeking convenient access to top-tier medical facilities or looking for comfortable surroundings during your stay, choosing the right neighborhood can enhance your visit. Each area provides a distinctive atmosphere, combining modern amenities with easy access to local attractions. When booking your vacation rentals in this dynamic part of Orlando, you can enjoy a seamless experience with reliable accommodations that cater to your needs, making your trip both enjoyable and effortless.

Lake Nona

Located within this vibrant region, your stay offers convenient access to a thriving community known for its innovation and modern amenities. It’s an ideal choice for travelers seeking comfort and connectivity in a dynamic area.

View 47+ Rentals in Lake Nona

Southeast Orlando

This part of the city provides a relaxed yet accessible environment, making it perfect for those looking to explore the area's diverse attractions while enjoying comfortable vacation rentals nearby.

View 196+ Rentals in Southeast Orlando

Best Times to Visit Lake Nona Medical City

When should you plan your Vacation Rentals stay?

Timing your visit to this destination can greatly enhance your experience, so consider planning your stay during the shoulder seasons when the region offers pleasant weather and fewer crowds for a more relaxing getaway.

Peak Season Highlights

spring
Spring (March to May)

This is the most popular time to visit due to the pleasant weather, making it ideal for exploring local amenities and enjoying outdoor activities in the area.

Average Temperature Daytime: 75-85°F - Nighttime: 55-65°F
winter
Winter Holidays (December to February)

During this season, you can experience cooler temperatures while avoiding the peak summer crowds, providing a more relaxed stay at your vacation rental here.

Average Temperature Daytime: 65-75°F - Nighttime: 45-55°F

Off-Season Highlights

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Summer (June to August)

In the summer months, the area sees fewer visitors, and you might enjoy more peaceful surroundings coupled with warm, inviting weather perfect for indoor or outdoor relaxation.

Average Temperature Daytime: 85-95°F - Nighttime: 70-80°F
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Fall (September to November)

During fall, the region experiences slightly quieter periods before the holiday season, offering an ideal balance of good weather and fewer crowds for your stay in the area.

Average Temperature Daytime: 70-80°F - Nighttime: 50-60°F

Weekly Weather Forecast for Lake Nona Medical City

How to Book Your Lake Nona Medical City Vacation Rental Home

What's our booking process?

Our platform allows you to browse a curated selection of vacation rentals. Once you find the ideal property, you’ll be redirected to a trusted booking partner to complete your reservation securely.

Booking Steps

01

Search Properties

Use our filters to find the right property that fits your needs.
02

Select a Rental

Click on your preferred listing to view details, amenities, and pricing.
03

Book Online

Follow the link to finalize your reservation directly on the partner’s website.

Explore and book the perfect rental in Lake Nona Medical City

More Top-Rated Vacation Rentals in Lake Nona Medical City Area

Common Vacation Rentals Amenities

What amenities can you expect?

Our Vacation Rentals are designed to offer all the comforts of home, often with added perks to make your stay unforgettable. Here’s some common amenities to look forward to:

Indoor Features

  • Fully-equipped kitchens with modern appliances
  • Comfortable living areas with flat-screen TVs
  • Free Wi-Fi for staying connected
  • Air conditioning and heating for year-round comfort
  • In-unit washers and dryers for convenience
  • Luxurious bedrooms with premium bedding
  • Spa-like bathrooms with soaking tubs or walk-in showers

Outdoor Amenities

  • Enjoy a refreshing dip in the outdoor swimming pool available at many properties here.
  • Take advantage of private or shared patios and decks for relaxing outdoor gatherings.
  • Explore beautifully maintained gardens or landscaped yards that enhance your outdoor experience.
  • Make use of designated grilling areas or outdoor kitchens for delicious barbecues under the sun.
  • Relax on loungers or chairs by the poolside or in scenic outdoor spaces.
  • If available, participate in outdoor fitness or yoga areas to stay active during your stay.
  • Benefit from access to walking trails or nearby parks for outdoor recreation and exploration.

Top Attractions Around Lake Nona Medical City

What attractions are nearby?

In this vibrant area, you can enjoy a variety of nearby activities such as exploring state-of-the-art medical facilities, experiencing local dining options, or strolling through scenic parks that highlight the region's natural beauty.

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Family Activities

  • Explore the Medical City Children's Museum: Engage your family with interactive exhibits designed to inspire learning and curiosity in a kid-friendly environment within this destination.
  • Visit Lake Nona's Sports and Recreation Complex: Enjoy outdoor activities such as tennis, basketball, or walking trails that cater to active families seeking fun and fitness in the area.
  • Discover Nature at Lake Nona Trails: Take a family walk or bike ride along scenic paths that showcase the natural beauty surrounding this region, perfect for outdoor adventures.
  • Enjoy a Family Picnic at Laureate Park: Relax and gather together in this vibrant community park, offering open green spaces and recreational facilities ideal for quality family time.
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Adult Activities

  • Medical City Exploration Tour: Discover the innovative healthcare and research facilities that make this destination a hub of medical advancements.
  • Golfing at Lake Nona Golf & Country Club: Enjoy a round of golf at this prestigious club, offering scenic views and challenging courses in the heart of the region.
  • Wine Tasting and Culinary Experiences: Indulge in local gourmet dining and wine tastings that highlight the region's vibrant culinary scene.
  • Enjoying Nature at Lake Nona Sports & Performance District: Engage in outdoor activities or relax amidst beautifully maintained parks and recreational spaces here.

Other Places to Stay in Lake Nona Medical City, FL

Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute Vacation Rentals
University of Central Florida College of Medicine
University of Central Florida College of Medicine Vacation Rentals
VA Medical Center at Lake Nona
VA Medical Center at Lake Nona Vacation Rentals
Nemours Children's Hospital
Nemours Children's Hospital Vacation Rentals
More Places to Stay Near Lake Nona Medical City

Lake Nona Medical City Travel Tips

How Can You Make the Most of Your Stay?

  • Visit Local Medical and Wellness Facilities: Take advantage of the area’s renowned healthcare institutions for wellness workshops or health-focused activities that can enhance your stay.
  • Explore Shopping and Dining Options Nearby: Discover the region's diverse dining venues and shopping centers to enjoy authentic local cuisine and convenient amenities during your visit.
  • Plan Your Transportation in Advance: Utilize the area's accessible transport options to navigate easily between your accommodation and key attractions or medical appointments.
  • Stay Close to Key Medical Institutions: Choose a vacation rental near major healthcare facilities to ensure convenience if you're visiting for medical purposes or appointments.

Transportation Options

  • Orlando International Airport (MCO): This major airport offers convenient domestic and international flights, making arrival and departure seamless for visitors staying nearby.
  • Local Shuttle Services: Reliable shuttle options operate within the region, providing easy transportation between your vacation rental and key destinations around the area.
  • Public Transit – Lynx Bus System: The extensive bus network offers affordable access to various parts of Orlando and the surrounding communities, including Lake Nona Medical City.
  • Rental Car Services: Numerous car rental agencies are available here, giving you the flexibility to explore the region at your own pace during your stay.

Local Customs Options

  • Polite Greetings and Handshakes: In this area, locals value respectful greetings such as a firm handshake and eye contact when meeting new people.
  • Celebration of Medical Achievements: The region takes pride in its medical advancements, often celebrating health-related milestones with community events and gatherings.
  • Casual Dress Code: You’ll find that casual, comfortable clothing is common here, especially around healthcare campuses and local amenities.
  • Emphasis on Cleanliness and Hygiene: Maintaining cleanliness is highly regarded, reflecting the area's focus on health and wellness within the community.

Frequently Asked Questions About Lake Nona Medical City?

1. What are the top vacation rentals in Lake Nona Medical City?

There are a lot of options in Lake Nona Medical City. If you plan on staying in the Lake Nona Medical City area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Lake Nona Medical City:

2. Which vacation homes in Lake Nona Medical City are best for families?

If you are looking for a family-friendly vacation home in Lake Nona Medical City, check out one of the following properties as all are highly-rated places to stay with excellent review for families or groups staying in Lake Nona Medical City:

3. How many Rentbyowner vacation rentals are available in Lake Nona Medical City?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 52 in the Lake Nona Medical City area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Lake Nona Medical City. 

4. What is the cancellation policy for vacation rentals in this area?

Cancellation policies vary depending on the listing, so it’s important to review the specific property's terms before booking. You can find detailed information and contact the host directly if you have any questions.

5. How do I contact the property owner for special requests or inquiries?

You can reach out to the property owner through the messaging platform provided during your booking process. This allows you to discuss any special requests or clarify details about your stay in the region.

6. Are there any check-in or check-out restrictions for staying in these vacation rentals?

Check-in and check-out times are set by the host and can differ from property to property. Be sure to review the listing details or contact the owner directly for specific arrangements.

7. Is Wi-Fi included in the rental amenities near the medical city area?

Most listings in this destination offer Wi-Fi as part of their amenities, but it's best to confirm with the property owner beforehand to ensure it meets your needs.

8. What amenities should I expect when booking a vacation rental here?

Amenities vary among properties, but common features include fully equipped kitchens, free parking, laundry facilities, and private outdoor spaces. Always check the listing details for a complete list of what’s included.