Discover Your Perfect Cleveland Clinic Vacation Homes

Best Vacation Homes in Cleveland Clinic

Why Choose Rent By Owner for your Cleveland Clinic Vacation Rental Homes?

What makes our Vacation Rentals special?

image
Verified Listings
Book with confidence knowing every property meets our quality and safety standards.
image
Unbeatable Value
Enjoy competitive pricing with no hidden fees, providing exceptional value for every stay.
image
Diverse Options
From cozy cabins to luxurious villas, find a rental that suits your style and needs.

Popular Areas for Cleveland Clinic Vacation Rentals

Where are the best neighborhoods to stay in Cleveland Clinic?

When planning your stay near the Cleveland Clinic, choosing the right neighborhood can enhance your overall experience. The area surrounding this world-renowned medical center offers a variety of neighborhoods that combine convenient access with local charm. Whether you're seeking vibrant urban energy or quiet residential streets, you’ll find options that suit your preferences. Staying in these neighborhoods allows you to enjoy the proximity to Cleveland Clinic while immersing yourself in the local community. Browse through reliable vacation rentals in this region to discover a comfortable and accessible home base during your visit to Cleveland, Ohio.

Downtown Cleveland

Staying in the heart of the city offers easy access to major businesses, cultural attractions, and entertainment options, making it an ideal choice for travelers seeking convenience and vibrant city life within reach.

View 769+ Rentals in Downtown Cleveland

University Circle

This area is perfect for exploring academic institutions, museums, and cultural landmarks, providing a sophisticated atmosphere and enriching experiences just moments from your lodging.

View 58+ Rentals in University Circle

Ohio City

Known for its lively neighborhoods and eclectic dining scene, Ohio City offers a dynamic setting where you can enjoy local breweries, trendy shops, and welcoming community vibes close by.

View 69+ Rentals in Ohio City

The Flats

Set along the riverfront, The Flats provides a trendy and lively environment with nightlife, outdoor activities, and scenic views, perfect for those wanting to experience the area's energetic spirit.

View 905+ Rentals in The Flats

University Heights

Offering a peaceful residential feel with convenient access to educational and cultural sites, this neighborhood is well-suited for visitors seeking a quiet yet connected stay in the region.

View 246+ Rentals in University Heights

Tremont

Characterized by its historic charm and artistic vibe, Tremont invites you to enjoy boutique shops, art galleries, and cozy eateries within a walkable community setting.

View 78+ Rentals in Tremont

Gateway District

Located at the city's core, the Gateway District is the hub of downtown activity, offering proximity to theaters, dining venues, and entertainment venues that bring the area's culture to life.

View 523+ Rentals in Gateway District

Asiatown

This vibrant neighborhood showcases diverse Asian cuisines, markets, and cultural events, providing a colorful and authentic experience for visitors exploring the region’s multicultural side.

View 517+ Rentals in Asiatown

Best Times to Visit Cleveland Clinic

When should you plan your Vacation Rentals stay?

Choosing the right time to visit here can greatly enhance your experience, allowing you to enjoy the region’s unique charm and activities at their best.

Peak Season Highlights

spring
Spring (March to May)

During the spring, you'll experience mild temperatures and blooming scenery, making it an ideal time to explore this destination’s local culture and attractions.

Average Temperature Daytime: 55°F to 70°F - Nighttime: 40°F to 50°F
autumn
Fall (September to November)

In the fall, the region offers crisp air and vibrant foliage, perfect for enjoying outdoor activities and comfortable stays in your vacation rentals.

Average Temperature Daytime: 60°F to 75°F - Nighttime: 45°F to 55°F

Off-Season Highlights

image
Summer (June to August)

While summer brings warm weather, it is also the busiest time of year. Booking early ensures you secure the best vacation rentals and avoid peak crowds.

Average Temperature Daytime: 75°F to 85°F - Nighttime: 60°F to 70°F
image
Winter (December to February)

During winter, cold temperatures and occasional snow create a quieter atmosphere, offering a peaceful retreat with cozy vacation rentals available for your stay.

Average Temperature Daytime: 30°F to 40°F - Nighttime: 20°F to 30°F

Weekly Weather Forecast for Cleveland Clinic

How to Book Your Cleveland Clinic Vacation Rental Home

What's our booking process?

Our platform allows you to browse a curated selection of vacation rentals. Once you find the ideal property, you’ll be redirected to a trusted booking partner to complete your reservation securely.

Booking Steps

01

Search Properties

Use our filters to find the right property that fits your needs.
02

Select a Rental

Click on your preferred listing to view details, amenities, and pricing.
03

Book Online

Follow the link to finalize your reservation directly on the partner’s website.

Explore and book the perfect rental in Cleveland Clinic

More Top-Rated Vacation Rentals in Cleveland Clinic Area

Common Vacation Rentals Amenities

What amenities can you expect?

Our Vacation Rentals are designed to offer all the comforts of home, often with added perks to make your stay unforgettable. Here’s some common amenities to look forward to:

Indoor Features

  • Fully-equipped kitchens with modern appliances
  • Comfortable living areas with flat-screen TVs
  • Free Wi-Fi for staying connected
  • Air conditioning and heating for year-round comfort
  • In-unit washers and dryers for convenience
  • Luxurious bedrooms with premium bedding
  • Spa-like bathrooms with soaking tubs or walk-in showers

Outdoor Amenities

  • Enjoy outdoor dining areas perfect for savoring meals while surrounded by the scenic views of the region.
  • Relax on a private patio or balcony, ideal for unwinding after exploring nearby attractions.
  • Take advantage of well-maintained gardens or landscaped yards to add a touch of nature to your stay.
  • Make use of outdoor grills for barbecues, great for social gatherings with family and friends.
  • Benefit from access to a spacious yard or lawn, suitable for outdoor activities or playing sports.
  • Discover designated fire pits for cozy evenings under the stars within the comfort of your rental property.
  • Utilize outdoor seating areas that provide a peaceful setting to relax and enjoy the area's fresh air.

Top Attractions Around Cleveland Clinic

What attractions are nearby?

While staying nearby, you'll find a variety of engaging activities in the region, from exploring local parks and cultural institutions to enjoying diverse dining experiences—all conveniently accessible from your Cleveland Clinic accommodation.

image
image

Family Activities

  • Rock and Roll Hall of Fame: Discover the history of music with interactive exhibits and iconic memorabilia that will captivate the entire family in this nearby cultural landmark.
  • Cleveland Museum of Natural History: Engage with fascinating exhibits on dinosaurs, wildlife, and space exploration, making it a perfect educational outing for children and parents alike.
  • Edgewater Park: Spend a relaxing day outdoors by the lake at this scenic park featuring playgrounds, picnic areas, and stunning views of Lake Erie, ideal for family leisure time.
  • The Children's Museum of Cleveland: Ignite your children's curiosity with hands-on exhibits and creative activities designed to entertain and educate throughout your stay in the region.
image

Adult Activities

  • Exploring the Cleveland Museum of Art: You can immerse yourself in world-class art collections that showcase both classical and contemporary masterpieces, perfect for a relaxing cultural experience near your vacation rental.
  • Enjoying the Cleveland Botanical Garden: Take a leisurely stroll through stunning gardens and indoor glasshouses, offering a peaceful retreat just minutes from your accommodation in this vibrant region.
  • Visiting the Rock and Roll Hall of Fame: Delve into musical history at this iconic museum, which provides engaging exhibits and interactive displays for music enthusiasts staying nearby.
  • Relaxing at Edgewater Park: Spend a day by the lake with scenic views and outdoor activities, ideal for unwinding during your stay here in Cleveland’s scenic waterfront area.

Cleveland Clinic Travel Tips

How Can You Make the Most of Your Stay?

  • Plan Ahead for Local Transportation: To make the most of your stay, familiarize yourself with the area's public transportation options or consider renting a vehicle for easy access to top attractions and nearby amenities.
  • Explore Nearby Dining and Shopping: Take advantage of the region’s diverse culinary scene and local shops to enjoy authentic experiences without straying far from your vacation rental.
  • Schedule Visits to Key Medical Facilities: If visiting the Cleveland Clinic is part of your trip, book appointments or tours in advance to ensure smooth and stress-free visits during your stay.
  • Stay Connected with Local Events: Check out community events or cultural activities happening in the area to enrich your visit and create memorable experiences at your vacation rental.

Transportation Options

  • RTA Light Rail Transit (LRT): The LRT provides quick and convenient access to Cleveland Clinic from various parts of the city, making it an ideal choice for easy transportation during your stay.
  • Bus Services: The regional bus network offers extensive routes around the area, allowing you to explore Cleveland Clinic's surroundings without hassle.
  • Taxis and Ride-Sharing Services: Taxis and popular ride-sharing apps like Uber and Lyft are readily available nearby, offering flexible and direct transportation options to and from the clinic.
  • Car Rentals: Renting a car gives you the freedom to navigate the region at your own pace, with numerous rental agencies conveniently located close to Cleveland Clinic.

Local Customs Options

  • Hospitality and Politeness: Locals here value courteous interactions, so maintaining respectful manners is appreciated when engaging with residents or staff at medical or community facilities.
  • Respect for Diversity: The area embraces diverse backgrounds and cultures, encouraging visitors to approach all individuals with openness and understanding during their stay.
  • Community Engagement: Participating in local events or supporting regional initiatives demonstrates an appreciation for the area's community spirit.
  • Cultural Awareness: Familiarizing yourself with local customs and etiquette enhances your experience and shows respect for the traditions here.

Frequently Asked Questions About Cleveland Clinic?

1. What are the top vacation rentals in Cleveland Clinic?

There are a lot of options in Cleveland Clinic. If you plan on staying in the Cleveland Clinic area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Cleveland Clinic:

2. How many Rentbyowner vacation rentals are available in Cleveland Clinic?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 649 in the Cleveland Clinic area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Cleveland Clinic. 

3. What is the cancellation policy for vacation rentals near Cleveland Clinic in Cleveland?

The cancellation policy varies depending on the specific property owner. It is recommended to review the terms listed on the property’s page or contact the host directly for detailed information regarding cancellations.

4. How do I find vacation rentals with flexible booking options close to Cleveland Clinic?

You can filter your search by selecting options such as free cancellation or flexible dates to find properties that best suit your travel plans while staying in this region.

5. Are there any additional fees I should be aware of when booking a vacation rental in this area?

Additional fees, including cleaning fees or security deposits, are typically specified in the listing details. It’s advisable to review these details carefully before confirming your reservation.

6. What amenities are generally available in vacation rentals near Cleveland Clinic?

Most properties offer essential amenities such as Wi-Fi, parking, and kitchen facilities. For specific amenities, please check each listing to ensure it meets your needs.

7. How far in advance should I book a vacation rental near Cleveland Clinic for peak visiting times?

It is recommended to book several months ahead during peak seasons or special events to secure your preferred accommodation and ensure availability in this destination.

Best Vacation Homes in Cleveland Clinic

10.0 (1 Review)
House
Trendy Midtown Lofts
  • Air Conditioner
  • Parking
  • Pet Friendly
View Availability
10.0 (11 Reviews)
Apartment
Trendy Midtown Loft
  • Air Conditioner
  • Parking
  • Pet Friendly
View Availability