La Mesa Vacation Rentals

Compare Vacation Rentals & Rent By Owner Homes in La Mesa, California, USA

La Mesa Hillside Escape
From£336 per night
New
4 Bedrooms 6 Guests
Best Western Plus La Mesa San Diego
8.4 (1010 Reviews)
1 Bedroom 2 Guests
The Owl House
From£69 per night
|
10.0 (5 Reviews)
1 Bedroom 2 Guests
Holiday Inn Express La Mesa Near SDSU by IHG
|
8.2 (515 Reviews)
1 Bedroom 2 Guests
Pool Side Safari Cabin
From£121 per night
10.0 (65 Reviews)
1 Bedroom 4 Guests
Designer 4 BR La Mesa Home w/Yard and BBQ
|
10.0 (3 Reviews)
4 Bedrooms 9 Guests
Motel 6 La Mesa, CA - San Diego
7.4 (997 Reviews)
1 Bedroom 2 Guests
Travel Writer's Pad
From£173 per night
10.0 (50 Reviews)
2 Bedrooms 6 Guests
San Diego Luxury Oasis
From£992 per night
|
10.0 (2 Reviews)
6 Bedrooms 30 Guests
Hidden King Suite with Garden, Parking - 4 Guest
10.0 (19 Reviews)
1 Bedroom 4 Guests
Downtown La Mesa gem
From£299 per night
|
10.0 (2 Reviews)
3 Bedrooms 8 Guests
Secret Garden~ Luxury Studio~Hot Tub Oasis🌴
10.0 (17 Reviews)
1 Bedroom 2 Guests
Modern and charming 1 bed first floor apartment
10.0 (2 Reviews)
1 Bedroom 4 Guests
Serenity - Amazing Views & Modern Charm
10.0 (2 Reviews)
1 Bedroom 3 Guests
5BR Oasis with Pool, Arcade, Sauna
|
10.0 (1 Review)
5 Bedrooms 20 Guests
25% off, Chic Casita Hot tub BBQ 4 min to SDSU
10.0 (7 Reviews)
1 Bedroom 4 Guests
Luxury 5br 3 5ba w Pool & Hot Tub
|
10.0 (1 Review)
4 Bedrooms 10 Guests
Luxe El Cajon Oasis w/Pool, Fire Pit & Pavilion
|
10.0 (1 Review)
3 Bedrooms 6 Guests
Agua Dulce - Mid Century Oasis - Pool &Hot Tub
|
10.0 (1 Review)
4 Bedrooms 10 Guests
The Helix House - Pool & Mountain Views
|
10.0 (1 Review)
2 Bedrooms 4 Guests
Stunning Guest House 15 min. from Zoo, Downtown
10.0 (4 Reviews)
1 Bedroom 2 Guests
The Agave House | Mountain Views & Pool
10.0 (3 Reviews)
1 Bedroom 2 Guests
La Mesa Townhome: 15 Mi to San Diego!
|
9.8 (11 Reviews)
2 Bedrooms 5 Guests
Chic, yet playful boho bungalow near everything!
10.0 (3 Reviews)
1 Bedroom 3 Guests
Charming 2 Room La Mesa Casita w/Pool, BBQ & Yard
|
9.8 (8 Reviews)
2 Bedrooms 4 Guests
Modern Oasis New 2BR in La Mesa
|
9.8 (6 Reviews)
2 Bedrooms 6 Guests
Nature Lovers Retreat
From£87 per night
10.0 (2 Reviews)
1 Bedroom 2 Guests
Echo by Coast to Cactus - Family-Friendly Home
|
9.5 (2 Reviews)
1 Bedroom 9 Guests
Charming La Mesa Cottage - Patio - Quiet District
10.0 (1 Review)
2 Bedrooms 6 Guests
Entire guesthouse in Spring Valley, California
10.0 (1 Review)
1 Bedroom 2 Guests
Grand House in Mt. Helix
From£298 per night
8.0 (1 Review)
2 Bedrooms 6 Guests
3 Bedroom House - Fire Pit Table BBQ - 10 Guests
|
9.2 (5 Reviews)
3 Bedrooms 10 Guests
Motel 6 La Mesa, CA
From£81 per night
7.2 (1003 Reviews)
1 Bedroom 2 Guests
Your own Suburban Oasis!
From£166 per night
8.0 (1 Review)
1 Bedroom 3 Guests
Designer Poolside 1Bed1Bth Retreat
|
9.0 (3 Reviews)
1 Bedroom 4 Guests
Heritage Inn La Mesa
From£52 per night
7.0 (1372 Reviews)
1 Bedroom 2 Guests
La Mesa Hillside Studio | Private Patio + Fast Wifi
8.0 (1 Review)
1 Bedroom 3 Guests
Fabulous Guesthouse in Mount Helix La Mesa
|
9.0 (3 Reviews)
2 Bedrooms 5 Guests
Crown Inn
From£52 per night
4.4 (18 Reviews)
1 Bedroom 2 Guests
Spacious El Cajon Villa - 14 Mi to Downtown!
|
9.0 (2 Reviews)
4 Bedrooms 15 Guests
Casa de Taft
8.9 (76 Reviews)
1 Bedroom 2 Guests
Colorful El Cajon Gem: Deck, Garden & Valley Views
|
8.5 (2 Reviews)
4 Bedrooms 12 Guests
Quaint La Mesa Home with Beautiful Sunsets!
|
8.4 (7 Reviews)
2 Bedrooms 6 Guests
Exotic home Rogers road
From£450 per night
|
7.0 (1 Review)
3 Bedrooms 8 Guests
Executive Retreat - Renovated - Spacious - Views
|
5.5 (2 Reviews)
1 Bedroom 9 Guests
San Diego Suite: Affordable quiet stay for 2
New
1 Bedroom 2 Guests
1BR Walkable to Downtown La Mesa
New
1 Bedroom 2 Guests

About La Mesa Vacation Rentals

With more than 410 La Mesa vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Rent By Owner Homes (RBOs) and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at an RBO property in La Mesa.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With RentByOwner La Mesa, you have the flexibility of comparing different options of various deals with a single click. Looking for an RBO with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner (RBOs), and other popular Airbnb-style properties in La Mesa. Places to stay near La Mesa are 1186.14 ft² on average, with prices averaging £347 a night.

RentByOwner makes it easy and safe to find and compare vacation rentals in La Mesa with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Frequently Asked Questions About La Mesa?

What are the top vacation rentals in La Mesa?

How many Rentbyowner vacation rentals are available in La Mesa?

Currently, the total number of properties listed by Rent By Owner in 2026 is over 410 in the La Mesa area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in La Mesa. 

Nearby Neighborhood (6)

NeighborhoodProperty Count
Mount Helix Vacation Rentals in La Mesa, California 197
San Carlos Vacation Rentals in La Mesa, California 63
Rolando Village Vacation Rentals in La Mesa, California 769
College East Vacation Rentals in La Mesa, California 715
Rolando Park Vacation Rentals in La Mesa, California 719
Windsor Hills Vacation Rentals in La Mesa, California 701