Charleston Vacation Rentals

Compare Vacation Rentals & Rent By Owner Homes in Charleston, Missouri, USA

Lambert’s Homestead. Very Cozy & Clean 5 bed home.
4.7 (26 Reviews)
3 Bedrooms 14 Guests
Drury Inn & Suites Sikeston
From£97 per night
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9.3 (801 Reviews)
155 Bedrooms 48 Guests
Drury Inn & Suites Sikeston, MO
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9.6 (1006 Reviews)
1 Bedroom 2 Guests
Tiny Home with Huge Outdoor Space
New
1 Bedroom 2 Guests
Comfort Inn & Suites Sikeston I-55
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8.1 (204 Reviews)
64 Bedrooms 16 Guests
Best Western Plus Sikeston I-55
8.4 (1002 Reviews)
1 Bedroom 2 Guests
Travel Inn and Suites- Sikeston Miner I-55 exit-67
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7.6 (449 Reviews)
37 Bedrooms 26 Guests
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 (749 Reviews)
1 Bedroom 2 Guests
Best Western Plus Sikeston I-55
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7.6 (295 Reviews)
37 Bedrooms 18 Guests
Comfort Inn & Suites Sikeston I-55
8.4 (291 Reviews)
1 Bedroom 2 Guests
Days Inn and Suites by Wyndham Sikeston
7.3 (235 Reviews)
26 Bedrooms 18 Guests
Days Inn and Suites by Wyndham Sikeston
7.2 (1002 Reviews)
1 Bedroom 2 Guests
Super 8 by Wyndham Sikeston/Miner Area
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7.0 (174 Reviews)
60 Bedrooms 21 Guests
Super 8 by Wyndham Charleston/Sikeston East MO
6.8 (626 Reviews)
1 Bedroom 2 Guests
Super 8 by Wyndham Charleston Sikeston East MO
6.4 (146 Reviews)
37 Bedrooms 13 Guests
Super 8 by Wyndham Sikeston/Miner Area
6.8 (601 Reviews)
1 Bedroom 2 Guests
The Riverstone Hotel
From£66 per night
6.4 (69 Reviews)
40 Bedrooms 22 Guests
The Riverstone Hotel Charleston-Sikeston
6.8 (410 Reviews)
1 Bedroom 2 Guests
Quality Inn Cairo I-57
From£53 per night
6.0 (48 Reviews)
38 Bedrooms 12 Guests
Country Yard Inn and Suite
From£50 per night
6.8 (126 Reviews)
1 Bedroom 2 Guests
Charleston Eagle Inn
From£404 per night
5.7 (13 Reviews)
5 Bedrooms 9 Guests
Eagle Inn Charleston
From£49 per night
6.6 (105 Reviews)
1 Bedroom 2 Guests
Country Yard Inn Sikeston - Miner Exit 67 on I-55
5.1 (108 Reviews)
44 Bedrooms 18 Guests
Quality Inn Cairo I-57
From£63 per night
6.4 (285 Reviews)
1 Bedroom 2 Guests
Pear Tree Inn Sikeston
From£64 per night
9.4 (1005 Reviews)
1 Bedroom 2 Guests

About Charleston Vacation Rentals

With more than 25 Charleston vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Rent By Owner Homes (RBOs) and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at an RBO property in Charleston.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With RentByOwner Charleston, you have the flexibility of comparing different options of various deals with a single click. Looking for an RBO with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner (RBOs), and other popular Airbnb-style properties in Charleston. Places to stay near Charleston are 157.16 ft² on average, with prices averaging £77 a night.

RentByOwner makes it easy and safe to find and compare vacation rentals in Charleston with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Frequently Asked Questions About Charleston?

What are the top vacation rentals in Charleston?

How many Rentbyowner vacation rentals are available in Charleston?

Currently, the total number of properties listed by Rent By Owner in 2026 is over 25 in the Charleston area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Charleston.